181, Dalvin Cook, MIN vs. TEN 9/27 (22 att., 1 TD)

168, Aaron Jones, GB vs. DET 9/20 (18 att., 2 TD)

151, Joe Mixon, CIN vs. JAC 10/4 (25 att., 2 TD)

138, Clyde Edwards-Helaire, KC vs. HOU 9/10 (25 att., 1 TD)

130, Dalvin Cook, MIN at HOU 10/4 (27 att., 2 TD)

124, Nick Chubb, CLE vs. CIN 9/17 (22 att., 2 TD)

121, Todd Gurley II, ATL vs. CAR 10/11 (14 att., 1 TD)

119, Derrick Henry, TEN at MIN 9/27 (26 att., 2 TD)

117, Sony Michel, NE vs. LAS 9/27 (9 att., 0 TD)

116, Derrick Henry, TEN at DEN 9/14 (31 att., 0 TD)

114, Darrell Henderson, LAR at BUF 9/27 (20 att., 1 TD)

113, Benny Snell Jr., PIT at NYG 9/14 (19 att., 0 TD)

112, Alexander Mattison, MIN at SEA 10/11 (20 att., 0 TD)

111, Ronald Jones II, TB vs. LAC 10/4 (20 att., 0 TD)

109, James Conner, PIT vs. HOU 9/27 (18 att., 1 TD)

108, Nick Chubb, CLE vs. WAS 9/27 (19 att., 2 TD)

107, Melvin Gordon III, DEN at NYJ 10/1 (23 att., 2 TD)

106, James Conner, PIT vs. DEN 9/20 (16 att., 1 TD)

106, Ronald Jones II, TB at CHI 10/8 (17 att., 0 TD)

103, Leonard Fournette, TB vs. CAR 9/20 (12 att., 2 TD)

102, James Robinson, JAC at TEN 9/20 (16 att., 1 TD)

101, Jonathan Taylor, IND vs. MIN 9/20 (26 att., 1 TD)

100, Damien Harris, NE at KC 10/5 (17 att., 0 TD)